Curcumin reduces acute pain and inflammation better than NSAID phenylbutazone (5)The anti-inflammatory activity of curcumin was evaluated in a group of patients who underwent surgery or suffered from trauma. A double-blind controlled-trial in which three groups received curcumin (400 mg/day), a placebo, or phenylbutazone (100 mg/day) for five consecutive days after surgery. Treatment with curcumin resulted in reduced inflammation more effectively than phenylbutazone. (5)Phenylbutazone is a powerful analgesic (painkiller) and an NSAID (nonsteroidal anti-inflammatory drug). Unlike NSAIDS, which have dangerous side-effects and black-box warnings, curcumin is safe and has no side-effects, even at doses up to 8,000 mg per day. (10, 11)References:
5. Satoskar R.R., et al. “Evaluation of anti-inflammatory property of curcumin in patients with post-operative inflammation,” Int. J. Clin. Pharmacol. Ther. Toxicol.: 24(12), 651-4, 1986.
10. Sarker, S.D., et al. “Bioactivity of Turmeric,” Turmeric: The genus Curcuma; Medicinal and aromatic plants–industrial profiles, edited by Ravindran, P.N., et al. Boca Raton, FL: CRC Press, 2007.
11. Cheng, A.L., et al. “Phase I clinical trial of curcumin, a chemoprotective agent, in patients with high-risk or pre-malignant lesions. Anti-cancer Res. 2001; July-Aug 21:2895-2900: www.ncbi.nlm.nih.gov/pubmed/11712783?dopt=Abstract.
A preliminary trial in people with rheumatoid arthritis found curcumin to be somewhat useful for reducing inflammation and symptoms such as pain and stiffness.8 A separate double-blind trial found that curcumin was superior to placebo or phenylbutazone (an NSAID) for alleviating post-surgical inflammation.9References:
8. Deodhar SD, Sethi R, Srimal RC. Preliminary studies on antirheumatic activity of curcumin (diferuloyl methane). Ind J Med Res 1980;71:632-4.
Numerous experimental studies have demonstrated